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    <lastmod>2025-01-27</lastmod>
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      <image:title>Home - Research in the Dolatshahi lab combines multiplex experimental measurements with computational methods (including statistical machine learning, network inference, information theory, signal processing and kinetic-dynamic modeling) to solve problems in the context of cancer, infectious disease and maternal-neonatal immunology.</image:title>
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      <image:title>Home - Thinking of joining our lab?</image:title>
      <image:caption>The Dolatshahi lab is looking for talented, enthusiastic, and diverse members to join their efforts. The lab’s priority is to provide training to highly motivated engineers and scientists who tackle real-world problems that closely impact people’s lives - and to have fun while doing so!  Prospective graduate students are encouraged to contact her: sdolatshahi@virginia.edu Graduate Students: We accept graduate student applications through the Department of Biomedical Engineering Ph.D. Program and the Biomedical Sciences Graduate Program (BIMS). Students interested in Systems Biology, Cancer Immunity, Computational Biology, Glycobiology, Biomedical Data Sciences, and Neonatal-Maternal Immunology are encouraged to contact Dr. Dolatshahi at sdolatshahi@virginia.edu with their resume/CV to discuss possible projects. Students with interest in working at the interface of experimental and computational immunology are particularly encouraged to apply. Postdoctoral Fellows: Highly motivated postdoctoral research candidates with strong background in experimental molecular and cellular biology/immunology (or a related discipline) and interest in learning computational methods are particularly encouraged to apply. Candidates with bioengineering or systems biology background and previous wet-lab experience are also strongly encouraged to apply. Candidates interested in postdoctoral research projects at the intersection of systems biology and immunology should send their CV and list of references to Dr. Dolatshahi at sdolatshahi@virginia.edu.</image:caption>
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    <lastmod>2022-04-06</lastmod>
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    <lastmod>2024-02-10</lastmod>
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      <image:title>Team_old</image:title>
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      <image:title>Team_old</image:title>
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  <url>
    <loc>https://www.dolatshahilab.com/anne-talkington-phd</loc>
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    <lastmod>2025-10-22</lastmod>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/624dba80cab79438641a060f/72d05a46-d1c7-4bc7-8c86-a63aea202120/UVA_Post_Doc_Headshots_AnneTalkington.jpg</image:loc>
      <image:title>Anne Talkington, Ph.D. - Anne Talkington, Ph.D.</image:title>
      <image:caption>Former Postdoctoral Fellow NIH T32 Immunology Training Grant T32AI007496-26A1 (2021-2022) Currently, Dr. Talkington is an Assistant Professor of Pharmaceutical Sciences at the University of Buffalo. When in the Dolatshahi lab, Dr. Anne Talkington’s research was focused on studying the mechanisms of interaction between tumor and immune cells, with the goal of understanding how these interactions correspond to treatment resistance in cancer.  She used a combination of mathematical modeling and data-based methods to associate tumor-immune interaction networks with the characteristics of a patient's tumor.  She aimed to understand interactions in the tumor microenvironment that could be better targeted to improve responsiveness to therapy, and thus, patient outcome. Prior to joining UVA, Anne completed her PhD in Computational Biology at UNC Chapel Hill, where she used a combination of physiologically-based pharmacokinetic modeling and experimental techniques to study adverse responses to PEGylated therapeutics as a result of anti-PEG antibodies.  She previously worked on differential equation models for immunotherapies as an undergraduate at Duke University.  Outside of lab, Anne loves the performing arts, and has spent most of her life training and performing in most styles of dance and musical theater!</image:caption>
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  <url>
    <loc>https://www.dolatshahilab.com/contact-2</loc>
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    <lastmod>2024-06-26</lastmod>
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  <url>
    <loc>https://www.dolatshahilab.com/research</loc>
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    <priority>0.75</priority>
    <lastmod>2024-09-02</lastmod>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/624dba80cab79438641a060f/019ad4a9-d782-4f0a-86cc-0afde07a0a18/Research1.png</image:loc>
      <image:title>Research - Systems Biology of Immune Factor Glycosylation and Intercellular Interactions in the Tumor Microenvironment</image:title>
      <image:caption>The role of micro-environmental interactions between tumor, stromal and immune cells have been extensively demonstrated in cancer growth, tissue remodeling, angiogenesis, migration, and tissue invasion. Tumor-inhibiting and tumor-promoting tumor-immune interactions have been identified as prognostic markers and immunotherapeutic targets such as checkpoint inhibitors. The prognostic and therapeutic success of these solutions, however, have been limited likely due to the highly complex stromal-tumor-immune interactions present in the tumor microenvironment (TME). The cellular interactions in the TME are mediated by ligand-receptor interactions, the complexities of which are further multiplied by the diverse post-translational modifications (PTM) of these secreted and cell-surface proteins. Glycosylation is one of the most common types of PTM and a critical determinant of the function of proteins, namely immune factors, such as immunoglobulins (Ig), tyrosine kinase receptors, integrins, and several other receptors and cytokines. Alterations in glycosylation are common in various cancer contexts and vary by disease progression. While protein glycosylation and TME alterations are known cancer hallmarks, a combined systems analysis of these inter-related changes is lacking. Accordingly, the overall goal of this project is to identify novel tumor-inhibiting or tumor-promoting interactions that are influenced by or impact glycosylation. These glycan-mediated interactions present novel markers for improved prognosis and introduce novel immunotherapeutic targets.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/624dba80cab79438641a060f/01e1e842-6b9a-4f55-be35-99e08e07c2bc/Research2_2.png</image:loc>
      <image:title>Research - Using systems immunology to understand immune reprogramming during pregnancy and the transplacental transfer of antibodies from mother to child</image:title>
      <image:caption>Systems serology attempts to quantify the entire humoral response via functional and biophysical assays. In a collaborative systems serology project, we set out to define the rules that govern transfer of antibody functionality across placenta from mother to child. We examined paired maternal and cord blood of a cohort of mothers and children for their antigen-specific immune profiles including: (a) antibody subclasses, (b) glycan profiles and the incurred antibody dependent phagocytosis by neutrophils and monocytes, (c) cytotoxicity and secretion of cytokines and chemokines by natural killer (NK) cells, and (d) complement deposition. Using Partial Least Squares Discriminant Analysis (PLSDA), we first defined the top contributors to the immune profile differences between moms and infants, including NK cell functions, IgG1 and doubly-galactosylated IgG. Next, we developed a statistical modeling framework that sets robust criteria to determine the active transfer, blocking or abundance-strict transfer of antibody attributes.</image:caption>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/624dba80cab79438641a060f/2fd7ea78-3a7c-4b9e-bff2-e78fc23a36fc/Research3.png</image:loc>
      <image:title>Research - Computational Biology – Multi-scale modeling of molecular and cellular networks</image:title>
      <image:caption>Emerging technologies to profile complex biological phenomena increasingly drive advances in biomedical sciences. These technologies provide multi-modal snapshots of biological systems at a range of spatial and temporal scales. To weave mechanistic stories based on a multitude of intracellular molecular measurements, inter-cellular, tissue-level and functional data, sophisticated computational methods are required. To this end, we combine multiplex experimental measurements with computational methods to solve problems in the context of cancer, infectious disease and maternal-neonatal immunology among others. A central paradigm of our research is development and testing of integrative computational models including data-driven statistical machine learning, network inference, information theory, and signal processing as well as bottom-up mechanistic kinetic-dynamic modeling.</image:caption>
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  <url>
    <loc>https://www.dolatshahilab.com/rob-barnes</loc>
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    <lastmod>2025-09-04</lastmod>
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      <image:title>Rob Barnes - Rob Barnes</image:title>
      <image:caption>BME Postdoctoral Researcher UVA BME Ph.D. student (Fall 2020- Summer 2025) UVA Cancer Center Trainee Fellow (2022-2023) Rob is a postdoctoral fellow in the Department of Biomedical Engineering (BME). He received his Ph.D. in BME in July 2025. His thesis work in the Dolatshahi Lab was titled “Systems Biology Approaches to Improving Immunotherapeutic Outcomes in Solid Tumors“.  Rob grew up in Atlanta, GA and Nashville, TN, and graduated from University of Georgia in Athens, GA in 2015 with a major in Biochemical Engineering. Prior to joining UVA, Rob worked for Juno Therapeutics in Seattle, WA as a process engineer. He was a member of the Viral Vector Process Development team and helped design adherent and suspension lentiviral production processes for use in CAR-T therapies.  Rob’s research focuses on immune cell behaviors in solid tumors. His work explores how the tumor microenvironment changes T cell and macrophage interactions with targeted immunotherapies.  His approach integrates single-cell transcriptomic analysis, mechanistic modeling, and genetic engineering to better understand cell-drug interactions. His projects have included an investigation into the dynamics of T cell inhibitory receptor expression, glycosylation-driven interference in macrophage-antibody interactions, and mechanisms of tertiary lymphoid structure development by cancer-associated fibroblasts. As a postdoc, Rob is working on furthering our understanding of macrophage glycosylation on antibody binding. He hopes to use his findings to better design antibodies to initiate immune reactions in solid tumors. Additionally, he is applying his expertise to help build models of antibody transfer across the placenta. Outside of lab, Rob spends most of his time skiing, fly fishing, and, when possible, scuba diving.</image:caption>
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    <lastmod>2026-04-03</lastmod>
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    <loc>https://www.dolatshahilab.com/remziye-erdogan</loc>
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    <lastmod>2025-09-04</lastmod>
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      <image:title>Remziye Erdogan - Remziye E Wessel</image:title>
      <image:caption>BME Ph.D. Student, Graduated in Summer 2025 Remziye graduated with her PhD from UVA BME in 2025. In the Dolatshahi Lab, she investigated placental antibody transfer dynamics using a blend of computational and experimental approaches toward the design of rational prenatal vaccine strategies. She is currently a postdoc in Doug Lauffenburger's lab at MIT where she is investigating how maternal and environmental exposures shape early life immune development and childhood vaccine efficacy. Remziye is passionate about both research and mentorship and looks forward to leading her own Systems Immunology lab one day! Outside of the lab, she enjoys exploring running trails with her dog Rosie, road cycling, crafting, and serving up new dishes at home for dinner. Email:  wesselr@mit.edu LinkedIn:  Remziye Wessel | LinkedIn Google Scholar:  ‪Remziye E Wessel‬ - ‪Google Scholar‬ Awards: Outstanding Biomedical Engineering Student Award (2025) Jill E. Hungerford Prize in Biomedical Sciences (One student receives this award out of all of the School of Medicine PhD students across departments). Endowed Victor Orphan Graduate Fellowship (2024-2025) Philanthropic Educational Organization (P.E.O.) Scholar award (2024-2025): one of the 100 women out of 827 school-selected nominees selected to receive a $25,000) American Society of Reproductive Immunology (ASRI) travel award (2024) Most helpful TA of the year, selected by the Undergraduate Biomedical Engineering Society at the BME formal (May 2024) NIH T32 Systems Biology and Data Science Training Grant T32GM145443 (2022-2023) American Society of Reproductive Immunology (ASRI) honorable mention poster award, 2022 Annual meeting Commonwealth of Virginia Cancer Research Conference (CVCRC) best oral presentation award (December 2023) SEAS “Engineering is Beautiful” art contest (May 2024) UVA Engineering School Dean’s Scholar (2020-2022)</image:caption>
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    <loc>https://www.dolatshahilab.com/shay-ladd</loc>
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    <lastmod>2025-10-22</lastmod>
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      <image:caption>BME PhD Student UVA Engineering School Dean’s Scholar (2022-2023) Systems and Biomolecular Data Science Trainee (2023-2024) UVA Engineering Teaching Fellowship Program Recipient (2025) Shay is a PhD student in the Biomedical Engineering department and joined the Dolatshahi Lab in 2022. She grew up in Blacksburg, VA, and graduated from Michigan State University in 2022 with a major in Chemical Engineering. She is passionate about teaching and hopes to pursue an academic career path. She is currently co-instructing and designing a new course about Systems Immunology and Engineering with Sepideh. Shay's research focuses on the role of glycosylation in cancer immunology. Specifically, she is studying the regulatory mechanisms surrounding the abnormal patterns of glycosylation that are frequently observed in cancer, as well as how these patterns influence interactions with the immune system and are affected by hypoxia. Understanding the transcriptional, epigenetic, and environmental factors that influence glycosylation could help to improve the efficacy and targeting of immunotherapies. Outside of the lab, Shay enjoys writing, crafting, baking (especially cookies!), and is always excited to find new things to experience.</image:caption>
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    <loc>https://www.dolatshahilab.com/gabe-hanson</loc>
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    <lastmod>2025-09-01</lastmod>
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      <image:title>Gabe Hanson - Gabe Hanson</image:title>
      <image:caption>BME Postdoctoral Researcher UVA BME Ph.D. student (Fall 2020- Summer 2025) Systems and Biomolecular Data Science Trainee (2023-2024) Gabe is a postdoctoral fellow in the Department of Biomedical Engineering (BME). He received his Ph.D. in BME in Summer 2025. His thesis work in the Dolatshahi Lab was titled “Integrative Spatial and Transcriptomic Profiling of Tumor-Immune Interactions in Lung Cancer“. Gabe is from Duluth, Minnesota, and graduated from Saint John’s University (MN) in 2016 with a degree in Applied Physics. Prior to joining UVA, Gabe spent a year living in monasteries in South Asia, serving as a volunteer in the Benedictine Volunteer Corps, and upon his return, worked as a project engineer at Open Systems International, where he designed and implemented multi-server supervisory control and data acquisition systems for power utility companies.  Gabe’s research is centered on understanding the coordination and communication of the immune system. His main project focuses on how immune interactions are rewired in lung cancer and how to better leverage the immune system to improve cancer treatment. He is also applying this framework to understand immune regulation and cross-talk at the maternal-neonatal interface.  Outside of the lab, you can find Gabe backpacking and hiking through the mountains near Charlottesville, playing the guitar, or tending to one of the many plants in his garden.</image:caption>
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    <image:image>
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    <image:image>
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  </url>
  <url>
    <loc>https://www.dolatshahilab.com/mary-osullivan</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2025-09-01</lastmod>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/624dba80cab79438641a060f/62052a0b-94ee-4da1-a169-8595732bc10c/MaryOSullivan.jpg</image:loc>
      <image:title>Mary O'Sullivan - Mary O’Sullivan</image:title>
      <image:caption>BME M.Sc. Student UVA Engineering School Distinguished Fellow (2023-2024) Systems and Biomolecular Data Science Trainee (2024-2025) Mary completed her M.Sc. studies in the Department of Biomedical Engineering in Summer 2025. She grew up in Colonial Beach, Virginia and graduated from Randolph-Macon College in 2023 with a major in Engineering and minors in Chemistry and Math. Mary’s research focused on cancer immunology. Specifically, she was looking at how immune checkpoint inhibitor (ICI) therapies may impact cell-cell crosstalk in the tumor microenvironment, which could help identify patient prognostics and suggest novel targets for supplementary immunotherapies. Outside of the lab, Mary enjoys hiking and going to the Charlottesville farmers markets, as well as spending time with her friends and family.</image:caption>
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  </url>
  <url>
    <loc>https://www.dolatshahilab.com/abigail-boyette</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2024-07-23</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/624dba80cab79438641a060f/253ab47b-92c0-4c86-a373-8d8b71e427e4/IMG_2444.jpg</image:loc>
      <image:title>Abigail Boyette - Abigail Boyette</image:title>
      <image:caption>Laboratory Specialist Abigail is a recent graduate from the UVA Biomedical Engineering program. She began with the Dolatshahi lab in June 2024. She was eager to join the team to aid with clinical trials related to tracking antibodies and other markers in maternal-neonatal immunology and to be of assistance in supporting the lab. Abigail grew up across three different states (VA, GA, and SC) but claims Charlottesville as her home. As one of seven siblings, she enjoys spending time with family and loves being an aunt. She also enjoys hosting, traveling, being involved in her church, and taking her dog (Striker) on outdoor adventures with her husband.</image:caption>
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  </url>
  <url>
    <loc>https://www.dolatshahilab.com/anna-sawik</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2024-07-22</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/624dba80cab79438641a060f/ed07fd4f-1957-4858-8634-83b3fd1c20d6/IMG_7164.jpg</image:loc>
      <image:title>Anna Sawik - Anna Sawik</image:title>
      <image:caption>Visiting Graduate Student BioLAB Trainee 2024-2025 Anna is in her final year of a Master's program at the Intercollegiate Faculty of Biotechnology (IFB UG &amp; MUG) in Gdańsk, Poland. She joined the Dolatshahi Lab in July 2024 as part of the BioLAB traineeship program. During her traineeship, Anna is contributing to a project focusing on maternal-neonatal immunology. Her primary task is to design a genetically modified trophoblast cell line that overexpresses the antibody receptor FCGR3A. This will allow her to explore the receptor's role in IgG transcytosis during the transplacental antibody transfer in pregnancy. In her free time, Anna enjoys sports, traveling, and spending time with friends. She also has a passion for reading and photography.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.dolatshahilab.com/caitlin-sullivan</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2025-10-22</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/624dba80cab79438641a060f/a397570f-3e3b-455f-81f8-603d1dab0bfe/UVA_BME_24Jan2025_ByTomDaly-111.jpg</image:loc>
      <image:title>Caitlin Sullivan - Caitlin Sullivan</image:title>
      <image:caption>BME Ph.D. Student Systems and Biomolecular Data Science Trainee (2025-2026) Caitlin is a PhD student in the Department of Biomedical Engineering. She grew up in Western Massachusetts and graduated from the University of Rhode Island with a degree in Pharmaceutical Sciences with a minor in Biological Sciences. Caitlin previously worked at various Biotech startups in Boston, supporting pre-clinical studies and assay development. Her work focused primarily on cancer vaccines and drug development for rare diseases of mineralization.  As a part of the Systems Immunology Lab at UVA, Caitlin's research focuses on maternal-neonatal immunology. Specifically, utilizing systems biology approaches to investigate how social determinants of health and demographic factors affect the placental and systemic immune landscape during pregnancy.  Outside of the lab, Caitlin enjoys connecting with long-distance friends through video games and spending time with her local friends (and their pets).  She also loves being an auntie to her brother's dog and human kids.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.dolatshahilab.com/emily-bubonovich</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2025-10-22</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/624dba80cab79438641a060f/b2f2e969-39a2-4463-984d-5477ad3bc7c5/Headshot.jpg</image:loc>
      <image:title>Emily Bubonovich - Emily Bubonivich</image:title>
      <image:caption>BME Ph.D. Student Emily is a PhD student in the Department of Biomedical Engineering and joined the Dolatshahi lab in 2025. She grew up in Natick, Massachusetts and graduated from the College of the Holy Cross with majors in Biology and Computer Science. At Holy Cross, she was also a member of the Varsity Women's Soccer team.  In the Systems Immunology Lab at UVA, her research focuses on fetal-maternal health, with a particular interest in understanding how social determinants of health and clinical factors influence immune response and architecture at the maternal-fetal interface during pregnancy. Outside of the lab, Emily enjoys exercising and staying active, watching sports, cooking/baking, and hanging out with friends!</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.dolatshahilab.com/prerak-thakkar</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2025-10-22</lastmod>
  </url>
</urlset>

