Dolatshahi Systems Immunology Lab
Sepideh Dolatshahi, Ph.D.
Assistant Professor of Biomedical Engineering
University of Virginia, School of Medicine
Core member of UVA Cancer Center
Member of UVA Carter Immunology Center
Principal Investigator
Bio
Assistant Professor of Biomedical Engineering 2020-present
Post-Doc Biological Engineering, MIT and MGH 2016-2019
Ph.D. Electrical Engineering, Georgia Tech 2015
M.S. Bioengineering, Georgia Tech 2013 & M.S. Electrical Engineering, U. Mass Amherst 2009
B.S. Electrical Engineering, University of Tehran 2007
Current Lab Members
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Sepideh Dolatshahi, Ph.D.
PRINCIPAL INVESTIGATOR
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Anne Talkington, Ph.D.
POSTDOCTORAL FELLOW
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Remziye Erdogan
PHD STUDENT
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Rob Barnes
PHD STUDENT
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Gabriel Hanson
PHD STUDENT
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Shay Ladd
PHD STUDENT
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Kate Goundry
UNDERGRADUATE RESEARCHER
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Esha Tulsian
UNDERGRADUATE RESEARCHER
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Sam Kaufman
UNDERGRADUATE RESEARCHER
Anne Talkington, Ph.D. , Postdoctoral fellow (2021-23), Immunology Training Grant awardee: Dr. Anne Talkington’s research was focused on studying the mechanisms of interaction between tumor and immune cells, with the goal of understanding how these interactions correspond to treatment resistance in cancer. She used a combination of mathematical modeling and data-based methods to associate tumor-immune interaction networks with the characteristics of a patient's tumor. She aimed to understand interactions in the tumor microenvironment that could be better targeted to improve responsiveness to therapy, and thus, patient outcome. She is currently a Mathematician at the National Institute of Standards and Technology, and will go on to start her faculty position after that.
Shri Ramanujam, UG researcher 2022-23: Shri’s research was aimed at optimizing assays for the genetic engineering of cell lines to modulate their glycosylation pattern. Outside of school/research, she loves reading, Taylor Swift, and woodworking!
Valeria Pabon, UG researcher, Spring 2022: Valeria’s research under the supervision of Rob Barnes in the Dolatshahi lab was focused on the analysis of CITE-seq data to uncover the interaction between bispecific antibody armed T cells and tumor cells. Outside of school/research, she enjoys playing soccer, volunteering as an EMT, and playing the saxophone in the marching band.
Lavie Ngo, NSF REU Summer 2022: Lavie, a VCU undergraduate student, joined the Dolatshahi lab as part of the UVA Summer REU in Multi-Scale Systems Bioengineering and Biomedical Data Sciences program. She presented her work titled “miRNA Regulation of Glycosylation Genes in Cancer Cell Lines“ at the UVA BME 4S seminar series as well as a poster at the BMES conference in October of 2022.
Danna Du, Undergraduate Researcher: Danna ‘s research was focused on the protocol optimization for maternal blood sample collection, as part of our neonatal-maternal immunity project. Sarah was part-time researching in our lab from March -June 2022. She joined a master’s in Biomedical Engineering program at UCLA in Fall 2022.
Joshua Ferey, M.D. Joshua was a medical student at the UVA School of Medicine. He worked on a review paper focused on the computational methods to infer and model inter-cellular interactions in the tumor microenvironment. He is currently doing his residency at the University of Maryland Medical Center.
Sarah Ames, Undergraduate Researcher: Sarah joined our lab in the summer of 2020 and focused on neonatal-maternal immunity research. She is now a Product Development Engineer at restor3d.
Aubrey Winger, Undergraduate Researcher: Aubrey joined the Dolatshahi lab in summer 2020. She studied the perturbation of glycosylation genes in non-small cell lung carcinoma in TCGA gene expression data.
Sarah Meng, Undergraduate Researcher: Sarah’s research was focused on developing a kinetic-dynamic model of the bispecific antibody therapeutics. Sarah started her Ph.D. at the University of Texas at Austin in Fall 2021.
Medhini Rachamallu, Undergraduate Researcher: Medhini’s research was focused on using unsupervised computational methods to study the perturbation of glycosylation genes in skin cancers using TCGA data.
Abigail Cordiner, NSF REU Summer 2021: Abigail was an NSF REU from North Carolina State University, co-mentored by the Pierce-Cottler lab. Under the supervision of her Ph.D. mentor, Remziye, she developed an agent-based model (ABM) of the transplacental transfer of antibodies in the Dolatshahi lab. She presented her poster titled “New Insights into IgG1 Transport Across Placenta Using Agent-Based Modeling” at BMES 2021.
“It all begins with an idea. Maybe you want to launch a business.”
Keith Finley
Anne Talkington, Ph.D. , Postdoctoral fellow (2021-23), Immunology Training Grant awardee: Dr. Anne Talkington’s research was focused on studying the mechanisms of interaction between tumor and immune cells, with the goal of understanding how these interactions correspond to treatment resistance in cancer. She used a combination of mathematical modeling and data-based methods to associate tumor-immune interaction networks with the characteristics of a patient's tumor. She aimed to understand interactions in the tumor microenvironment that could be better targeted to improve responsiveness to therapy, and thus, patient outcome. She is currently a Mathematician at the National Institute of Standards and Technology, and will go on to start her faculty position after that.
Shri Ramanujam, UG researcher 2022-23: Shri’s research was aimed at optimizing assays for the genetic engineering of cell lines to modulate their glycosylation pattern. Outside of school/research, she loves reading, Taylor Swift, and woodworking!
Aubrey Winger, Undergraduate Researcher: Aubrey joined the Dolatshahi lab in summer 2020. She studied the perturbation of glycosylation genes in non-small cell lung carcinoma in TCGA gene expression data.
Sarah Meng, Undergraduate Researcher: Sarah’s research was focused on developing a kinetic-dynamic model of the bispecific antibody therapeutics. Sarah started her Ph.D. at the University of Texas at Austin in Fall 2021.
Medhini Rachamallu, Undergraduate Researcher: Medhini’s research was focused on using unsupervised computational methods to study the perturbation of glycosylation genes in skin cancers using TCGA data.
Abigail Cordiner, NSF REU Summer 2021: Abigail was an NSF REU from North Carolina State University, co-mentored by the Pierce-Cottler lab. Under the supervision of her Ph.D. mentor, Remziye, she developed an agent-based model (ABM) of the transplacental transfer of antibodies in the Dolatshahi lab. She presented her poster titled “New Insights into IgG1 Transport Across Placenta Using Agent-Based Modeling” at BMES 2021.
Anne Talkington, Ph.D. , Postdoctoral fellow (2021-23), Immunology Training Grant awardee: Dr. Anne Talkington’s research was focused on studying the mechanisms of interaction between tumor and immune cells, with the goal of understanding how these interactions correspond to treatment resistance in cancer. She used a combination of mathematical modeling and data-based methods to associate tumor-immune interaction networks with the characteristics of a patient's tumor. She aimed to understand interactions in the tumor microenvironment that could be better targeted to improve responsiveness to therapy, and thus, patient outcome. She is currently a Mathematician at the National Institute of Standards and Technology, and will go on to start her faculty position after that.
Shri Ramanujam, UG researcher 2022-23: Shri’s research was aimed at optimizing assays for the genetic engineering of cell lines to modulate their glycosylation pattern. Outside of school/research, she loves reading, Taylor Swift, and woodworking!
Valeria Pabon, UG researcher, Spring 2022: Valeria’s research under the supervision of Rob Barnes in the Dolatshahi lab was focused on the analysis of CITE-seq data to uncover the interaction between bispecific antibody armed T cells and tumor cells. Outside of school/research, she enjoys playing soccer, volunteering as an EMT, and playing the saxophone in the marching band.
Lavie Ngo, NSF REU Summer 2022: Lavie, a VCU undergraduate student, joined the Dolatshahi lab as part of the UVA Summer REU in Multi-Scale Systems Bioengineering and Biomedical Data Sciences program. She presented her work titled “miRNA Regulation of Glycosylation Genes in Cancer Cell Lines“ at the UVA BME 4S seminar series as well as a poster at the BMES conference in October of 2022.
Danna Du, Undergraduate Researcher: Danna ‘s research was focused on the protocol optimization for maternal blood sample collection, as part of our neonatal-maternal immunity project. Sarah was part-time researching in our lab from March -June 2022. She joined a master’s in Biomedical Engineering program at UCLA in Fall 2022.
Joshua Ferey, M.D. Joshua was a medical student at the UVA School of Medicine. He worked on a review paper focused on the computational methods to infer and model inter-cellular interactions in the tumor microenvironment. He is currently doing his residency at the University of Maryland Medical Center.
Sarah Ames, Undergraduate Researcher: Sarah joined our lab in the summer of 2020 and focused on neonatal-maternal immunity research. She is now a Product Development Engineer at restor3d.
Aubrey Winger, Undergraduate Researcher: Aubrey joined the Dolatshahi lab in summer 2020. She studied the perturbation of glycosylation genes in non-small cell lung carcinoma in TCGA gene expression data.
When we got a chance to take photos!
Lab outing, Nov 2023
Partial lab photo, Xmas 2023
Remziye & Sepideh, AAI May 2023
Gabe @ BMES, Oct 2023
Rob @ AAI 2023
Remziye podium talk award at CVCRC, Dec 2023
Lab meeting photo, Nov 2023
Shay @ CVCRC, Dec 2023
Lab dinner, Jun 2022
Rob @ AAI 2022
Lab hike, Spring 2022
Sepideh wins the 2023 Chambers-Thermo Fisher Scientific Award
Master of Data Science student team @ the Dolatshahi lab, 2022
Lab alumni
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Shri Ramanujam, UG researcher 2022-23
Shri’s research was aimed at optimizing assays for the genetic engineering of cell lines to modulate their glycosylation pattern. Outside of school/research, she loves reading, Taylor Swift, and woodworking!
-
Valeria Pabon, UG researcher, Spring 2022
Valeria’s research under the supervision of Rob Barnes in the Dolatshahi lab was focused on the analysis of CITE-seq data to uncover the interaction between bispecific antibody armed T cells and tumor cells. Outside of school/research, she enjoys playing soccer, volunteering as an EMT, and playing the saxophone in the marching band.
-
Lavie Ngo, NSF REU Summer 2022
Lavie, a VCU undergraduate student, joined the Dolatshahi lab as part of the UVA Summer REU in Multi-Scale Systems Bioengineering and Biomedical Data Sciences program. She presented her work titled “miRNA Regulation of Glycosylation Genes in Cancer Cell Lines“ at the UVA BME 4S seminar series as well as a poster at the BMES conference in October of 2022.
-
Danna Du, Undergraduate Researcher
Danna ‘s research was focused on the protocol optimization for maternal blood sample collection, as part of our neonatal-maternal immunity project. Sarah was part-time researching in our lab from March -June 2022. She joined a master’s in Biomedical Engineering at UCLA in Fall 2022.
-
Joshua Ferey, M.D.
Joshua was a medical student at the UVA School of Medicine. He worked on a review paper focused on the computational methods to infer and model inter-cellular interactions in the tumor microenvironment. He is currently doing his residency at the University of Maryland Medical Center.
-
Sarah Ames, Undergraduate Researcher
Sarah joined our lab in the summer of 2020 and focused on neonatal-maternal immunity research. She is now a Product Development Engineer at restor3d.
-
Aubrey Winger, Undergraduate Researcher
Aubrey joined the Dolatshahi lab in summer 2020. She studied the perturbation of glycosylation genes in non-small cell lung carcinoma in TCGA gene expression data.
-
Sarah Meng, Undergraduate Researcher
Sarah’s research was focused on developing a kinetic-dynamic model of the bispecific antibody therapeutics. Sarah started her Ph.D. at the University of Texas at Austin in Fall 2021.
-
Medhini Rachamallu, Undergraduate Researcher
Medhini’s research was focused on using unsupervised computational methods to study the perturbation of glycosylation genes in skin cancers using TCGA data.
-
Abigail Cordiner, NSF REU Summer 2021
Abigail was an NSF REU from North Carolina State University, co-mentored by the Pierce-Cottler lab. Under the supervision of her Ph.D. mentor, Remziye, she developed an agent-based model (ABM) of the transplacental transfer of antibodies in the Dolatshahi lab. She presented her poster titled “New Insights into IgG1 Transport Across Placenta Using Agent-Based Modeling” at BMES 2021.
Thinking of joining our lab?
The Dolatshahi lab is looking for talented, enthusiastic and diverse members to join their efforts. The lab’s priority is to provide training to highly motivated engineers and scientists who tackle real-world problems that closely impact people’s lives - and to have fun while doing so! Prospective graduate students are encouraged to contact her: sdolatshahi@virginia.edu